Short history of L-Dopa
by
Unidad de Movimientos Anormales,
Servicio de Neurologia,
Fundacion Jimenez Diaz, Madrid, Spain.
pgarcia@fjd.es
Neurologia. 2002 Apr;17(4):214-7


ABSTRACT

The introduction of L-Dopa has been a landmark in Neuroscience. Before the use of L-Dopa, Parkinson's disease (PD) was considered a disabling disease with no effective treatment. The development of L-Dopa followed a rationale approach: first, the discovery of dopamine deficiency in the striatum of patients with PD; and then the use of precursor of dopamine. Overall, the whole process took less than 12 years; this is a remarkable short time taking into account that the development of a similar crucial drug such as insulin took 50 years. In addition, the success of L-Dopa stimulated the neurochemistry research for all neurodegenerative diseases. .


L-DOPA
Rasagiline
Neuroprotection
MAO-b inhibitors/PD
Rasagiline pharmacology
Induction of pro-survival genes
Rasagiline and the mitochondria
Antioxidant strategies against aging
Anti-Alzheimer/anti-Parkinson's drugs
Rasagiline versus selegiline metabolites


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