Clinical applications of MAO-inhibitors
by
Riederer P, Lachenmayer L, Laux G.
Clinical Neurochemistry,
Dept. Psychiatry, Univ. Wuerzburg,
Wuerzburg, Germany.
peter.riederer@mail.uni-wuerzburg.de
Curr Med Chem. 2004 Aug;11(15):2033-43.


ABSTRACT

Monoamine oxidase inhibitors (MAO-I) have been useful in the treatment of both psychiatric and neurological disorders over centuries. Here we focus on the development of this drug treatment. Focus is given on the use of irreversible MAO-I's as well as on reversible ones. Benefit and side effects are reported for Parkinson's disease, Alzheimer's dementia, depression syndrome and panic disorders. The preclinical and clinical effects of selegiline with regard to neuroprotection are highlightened and the conclusion is drawn that there is good evidence for a clinical neuroprotective capacity based on the assumption that the 50 percent recovery of MAO-B is obtained already after a 10 days withdrawal of selegiline. There is also a focus on selegiline's metabolism to amphetamine and metamphetamine. In order to avoid any such effects of metabolic compounds on the cardiovascular system Zydis Selegiline, a melt-tablet avoid of major metabolism to amphetamine and metamphetamine is described in detail. Developments in MAO-I research are discussed in detail as there are moclobemide, lazabemide, rasagiline. Interactions of MAO-I' with tricyclics and serotonin selective reuptake inhibitors (SSRI's) are described as there is mentioning of interactions of MAO-I's with other compounds in general. Tables and figures report on clinical studies and on pharmacological properties of MAO-I's.


MAO-B
Rasagiline
Neuroprotection
MAO types A and B
MAO-B inhibitors/PD
Molecular mechanisms
Rasagiline pharmacology
Induction of pro-survival genes
Rasagiline and the mitochondria
Antioxidant strategies against aging
MAO research and genetic engineering
Rasagiline (Agilect, Azilect) for Parkinson's disease


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